“Small Fiber Neuropathy Market” has been added to DelveInsight
Small Fiber Neuropathy Overview
Small Fiber Neuropathy (SFN) is a condition that generally affects the nervous system and is marked by severe pain attacks. It occurs when damage to the peripheral nerves predominantly or entirely affects the small myelinated (Aδ) fibers or unmyelinated C fibers thus called as Small Fiber Peripheral Neuropathy. It generally affects the small nerve fibers present in the skin and those responsible to mediate pain and thermal sensation. The specific fiber types involved in this process include both small somatic and autonomic fibers.
Small Fiber Neuropathy Market: Forecast
DelveInsight’s “Small Fiber Neuropathy (SFN) – Market Insights, Epidemiology, and Market Forecast-2030” report delivers an in-depth understanding of the Small Fiber Neuropathy (SFN) , historical and forecasted epidemiology as well as the Small Fiber Neuropathy (SFN) market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan
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Small Fiber Neuropathy Market: Regions Covered
Small Fiber Neuropathy Market: Report
SFN is caused by mutations in the SCN9A or SCN10A gene. Both the gene instructs the production of the alpha subunit for the NaV1.7 sodium channel. The SCN9A gene mutations result in NaV1.7 sodium channels that do not close completely when the channel is turned off and many SCN10A gene mutations results in opening of NaV1.8 sodium channels that more easily than usual. This increase in sodium ions enhances transmission of pain signals, causing individuals to be more sensitive to stimulation.
SFN is mainly associated with autoimmune diseases, sodium channel gene variants, diabetes mellitus, and vitamin B12 deficiencies, although in more than one-half of patients no etiology can be identified. Based on these etiologies, it can be divided in to four sub-groups such as Acquired SFN, Hereditary SFN, Syndromic SFN, and Idiopathic SFN.
Small Fiber Neuropathy Market: Symptoms
The symptoms of SFN include bowel problems, urinary issues, rapid heartbeat, abnormal sweating, and dry eyes and mouth. It is generally characterized by severe pain attacks that begin in the feet or hands.
Small Fiber Neuropathy Key Strengths
Small Fiber Neuropathy Market: Treatment
There is no cure for SFN. The frequency of SFN is not clearly known and it can vary according to ethnicity and gender. The progressiveness of this disease and its complications cause debilitating effects on the health of patients and impose a significant burden, both economically and on the quality of life. Thus, a lot of research has been done in this space to find the ways to manage the disease. Pain management and other symptomatic therapies are main components of the treatment system for patients with neuropathy. Non-pharmacological therapies such as transcutaneous electrical nerve stimulation, acupuncture, physical therapy and massage, and others are also used.
Small Fiber Neuropathy Market: Insights
Head-to-head trials of medications and long-term outcome data for small fiber neuropathies are lacking. When possible, disease-specific treatment guidelines should be selected for management of pain in small fiber neuropathy (e.g., diabetes, HIV, or chemotherapy). At present, therapeutic strategies are largely symptomatic. Three main categories of drugs are most commonly used for treating neuropathic pain: antidepressants, anti-epileptics, and opioids.
Small Fiber Neuropathy Market: Key Players
Small Fiber Neuropathy Market: Drugs
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