DelveInsight has recently published a report on “Zenocutuzumab Market Forecast Report” providing an in-depth analysis of the Zenocutuzumab market analysis and forecasts up to 2032 in the seven major markets (7MM) (i.e. the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan. The comprehensive report provides an analysis of Zenocutuzumab market potential and market share analysis in the Rare NRG1 Fusion therapeutics space across the 7MM from 2019 to 2032.
The report also helps you to understand the Zenocutuzumab clinical and commercial developments along with parameters like the drug’s Mechanism of Action (MOA), Route of Administration (ROA), dosage, and special designations.
Interested in finding out the projected market size of Zenocutuzumab by 2032? Visit:Zenocutuzumab Market Forecast
Zenocutuzumab Drug Summary
Zenocutuzumab (MCLA-128) is an IgG1 bispecific antibody being developed by Merus. It blocks the action of the growth factor NRG1, a protein that can be overproduced due to NRG1 fusions, and prohibits it from binding to HER3. HER3 is a protein that sits on the surface of cancer cells, and when it combines with a second surface protein, HER2, it sends signals to drive tumor growth and survival. NRG1 induces the combination of HER2 and HER3.
Zenocutuzumab is a bispecific antibody, i.e., it can recognize two different proteins, specifically HER2 and HER3. It is designed to have a dock and block mechanism. First, zenocutuzumab (MCLA-128) docks onto HER2. Which then leads to blocking HER3’s ability to bind NRG1. In addition to its direct action on the cancer cell linking to HER2 and HER3, zenocutuzumab (MCLA-128) is manufactured in a way that aims to increase a patient’s own ability to attack cancer, called antibody-dependent cell-mediated cytotoxicity (ADCC) properties. Zenocutuzumab (MCLA-128) possesses enhanced ADCC activity (NRG1, n.d.).
Enrollment continues in the eNRGy trial of Zeno monotherapy in NRG1+ cancer and in a Phase II trial of Zeno in combination with androgen deprivation therapy (ADT) in castration resistant prostate cancer (CRPC) and in combination with afatinib in NRG1+ non-small-cell lung cancer (NSCLC).
In October 2022, Merus met with the US Food and Drug Administration (FDA) regarding a potential biologics license application (BLA) filing for Zeno in NRG1+ cancer. Based on the FDA’s feedback, Merus believes multiple registrational paths remain viable and has decided the optimal approach is to sequence its development plan by first seeking a potential application for NRG1+ lung and/or pancreatic cancer, which could then be followed by a potential tissue agnostic filing. The company believes Zeno has the potential to be both first in class and best in class and a new standard of care for the treatment of NRG1+ cancer.
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Rare NRG1 Fusion Market Outlook and Forecast
“Rare NRG1 Fusion Market Insights, Epidemiology and Market Forecast 2032” report delivers an in-depth understanding of Rare NRG1 Fusion, historical and forecasted epidemiology as well as the Rare NRG1 Fusion market trends in the United States, EU4 (Germany, Spain, Italy, and France), and the United Kingdom, and Japan. It also covers the key companies and emerging therapies in the Rare NRG1 Fusion therapeutics landscape.
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